The selectivity of these sites in mediating the disruptive effects as opposed to putative physiological roles of Aβ ( Puzzo et al., 2008 Giuffrida et al., 2010) is unclear. Several putative receptor sites have been proposed to mediate disruptive effects of Aβ on synaptic plasticity including proteoglycans ( Snow et al., 1995) receptor for advanced glycation end products ( Yan et al., 2009) LRP ( Deane et al., 2004) integrins ( Wright et al., 2007) and nicotinic ( Wang et al., 2000), NMDA ( Bi et al., 2002), insulin ( Xie et al., 2002), and p75 neurotrophin ( Yaar et al., 1997) receptors. The concentration of water-soluble Aβ oligomers, in particular SDS-stable Aβ dimers, is elevated in the brains of AD patients ( Mc Donald et al., 2010) and aqueous extracts of AD brain that contain such dimers powerfully inhibit long-term potentiation (LTP) in mouse hippocampal slices and impair avoidance learning in rats ( Shankar et al., 2008). Water-soluble nonfibrillar assemblies of Aβ have been found to be highly toxic to synapses, providing a basis for the positive correlation between disease severity and postmortem concentration of soluble Aβ ( Lue et al., 1999 McLean et al., 1999 Wang et al., 1999). The amyloid β-protein (Aβ) is strongly implicated in the cognitive decline of Alzheimer's disease (AD) ( Selkoe, 2002), and great effort has been expended in characterizing the most pathogenically important Aβ assemblies ( Shankar and Walsh, 2009). These data support the pathophysiological significance of SDS-stable Aβ dimer and the role of PrP C in mediating synaptic plasticity disruption by soluble Aβ. In contrast, R1, a Fab directed to the C terminus of PrP C, a region not implicated in binding of Aβ, did not significantly affect the Aβ-mediated inhibition of LTP. Importantly, intracerebroventricular administration of antigen-binding antibody fragment D13, directed to a putative Aβ-binding site on PrP C, prevented the inhibition of LTP by AD brain-derived Aβ. Moreover, the disruption of LTP was abrogated by immunodepletion of Aβ. Here we report that intracerebroventricular injection of Aβ-containing aqueous extracts of Alzheimer's disease (AD) brain robustly inhibits long-term potentiation (LTP) without significantly affecting baseline excitatory synaptic transmission in the rat hippocampus in vivo. Must be willing to rotate shifts, days off and work area may occasionally be required to work overtime.Synthetic amyloid-β protein (Aβ) oligomers bind with high affinity to cellular prion protein (PrP C), but the role of this interaction in mediating the disruption of synaptic plasticity by such soluble Aβ in vitro is controversial. Requires good judgment in delivering patient care good oral and written communication skills ability to function in stressful situations current review in CPR. Previous experience in general duty nursing preferred, but not required.Įmployee must demonstrate ability to recognize patients' individual needs based on medical conditions, age adolescents, young adults, middle-aged and geriatric), limitations and planned procedures. Graduate of an accredited program in nursing. Maintains standards of department and the hospital. Coordinates activities with ancillary departments. Coordinates and does patient teaching and discharge planning. As a Catholic hospital, we are here to create a spirit of healing.Ĭoordinates and delivers patient care using the health care team philosophy practice model. We offer career opportunities for people who have a calling to share their gifts and talents as part of our healing ministry. At St Dominic's Hospital, we offer you much more than just a job in the healthcare industry.
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